PF-04979064
A highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively; exhibits excellent in vitro potency, very good solubility, high LipE, excellent kinome selectivity, robust PK/PD correlation and TGI efficacy, and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism.
Product Specifications
CAS Number
1220699-06-8
Product Name Alternative
PF 04979064 | PF04979064
Purity
>98% (HPLC)
Solubility
DMSO: 11 mg/mL
Smiles
CC1=NC=C (C=C1) C2=NC3=C4C (=CN=C3C=C2) N (C (=O) N4C5CCN (CC5) C (=O) C (C) O) C
Molecular Formula
C24H26N6O3
Molecular Weight
446.5016
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[ (2S) -2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8- (6-methyl-3-pyridinyl) -
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