PF-04979064
A highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively; exhibits excellent in vitro potency, very good solubility, high LipE, excellent kinome selectivity, robust PK/PD correlation and TGI efficacy, and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism.
Product Specifications
CAS Number
1220699-06-8
Product Name Alternative
PF 04979064 | PF04979064
Purity
>98% (HPLC)
Solubility
DMSO: 11 mg/mL
Smiles
CC1=NC=C (C=C1) C2=NC3=C4C (=CN=C3C=C2) N (C (=O) N4C5CCN (CC5) C (=O) C (C) O) C
Molecular Formula
C24H26N6O3
Molecular Weight
446.5016
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[ (2S) -2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8- (6-methyl-3-pyridinyl) -
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
C18orf2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
Mouse MMP1 (Matrix Metalloproteinase 1) ELISA Kit
Mouse MMP1 (Matrix Metalloproteinase 1) ELISA Kit
Mouse MMP1 (Matrix Metalloproteinase 1) ELISA Kit
Mouse MMP1 (Matrix Metalloproteinase 1) ELISA Kit
