ML324
ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity) ; causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc) ; blocks TNF-α-mediated neutrophil adhesion, reduces TNF-α-induced ICAM1 protein expression in cerebral microvessels.
Product Specifications
CAS Number
1222800-79-4
Product Name Alternative
ML-324
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
O=C (NCCCN (C) C) C1=CC=C (C2=CC (O) =C3N=CC=CC3=C2) C=C1
Molecular Formula
C21H23N3O2
Molecular Weight
349.4262
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[3- (dimethylamino) propyl]-4- (8-hydroxy-6-quinolinyl) -
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