FLLL-32
FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM) ; induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.
Product Specifications
CAS Number
1226895-15-3
Product Name Alternative
JAK2 Inhibitor X | FLLL32
Purity
>98% (HPLC)
Solubility
DMSO: 85 mg/mL (183 mM) ; Ethanol: 24 mg/mL (51.7 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1 (C (/C=C/C2=CC=C (OC) C (OC) =C2) =O) CCCCC1) /C=C/C3=CC=C (OC) C (OC) =C3
Molecular Formula
C28H32O6
Molecular Weight
464.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2E,2'E) -1,1'-cyclohexylidenebis[3- (3,4-dimethoxyphenyl) ]-2-propen-1-one
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