Idasanutlin
Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM. (In Vitro) :Idasanutlin (RG7388) inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53. Idasanutlin (RG7388) (300 nM or 1.8 μM) induces apoptosis in SJSA osteosarcoma cells. (In Vivo) :Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model. Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model.
Product Specifications
CAS Number
1229705-06-9
Product Name Alternative
RG-7388
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (162.21 mM) ; Ethanol:8 mg/mL warmed (12.97 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
O=C (O) C1=CC=C (NC ([C@@H]2N[C@@H] (CC (C) (C) C) [C@] (C#N) (C3=CC=C (Cl) C=C3F) [C@H]2C4=CC=CC (Cl) =C4F) =O) C (OC) =C1
Molecular Formula
C31H29Cl2F2N3O4
Molecular Weight
616.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- ((2R,3S,4R,5S) -3- (3-chloro-2-fluorophenyl) -4- (4-chloro-2-fluorophenyl) -4-cyano-5-neopentylpyrrolidine-2-carboxamido) -3-methoxybenzoic acid.
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