Prexasertib dihydrochloride
A potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM; potently abrogates the G2-M checkpoint activated by doxorubicin in p53-deficient HeLa cells with EC50 of 9 nM; causes replication catastrophe in vitro and in vivo; shows significant tumor growth inhibition in xenograft tumor models.Lung Cancer Phase 2 Clinical.
Product Specifications
CAS Number
1234015-54-3
Product Name Alternative
LY-2606368 dihydrochloride | LY 2606368 dihydrochloride
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
COC1=C (C (=CC=C1) OCCCN) C2=CC (=NN2) NC3=NC=C (N=C3) C#N.Cl.Cl
Molecular Formula
C18H21Cl2N7O2
Molecular Weight
438.311
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Pyrazinecarbonitrile, 5-[[5-[2- (3-aminopropoxy) -6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-, hydrochloride (1:2)
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