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Prexasertib dihydrochloride

A potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM; potently abrogates the G2-M checkpoint activated by doxorubicin in p53-deficient HeLa cells with EC50 of 9 nM; causes replication catastrophe in vitro and in vivo; shows significant tumor growth inhibition in xenograft tumor models.Lung Cancer Phase 2 Clinical.

Product Specifications

CAS Number

1234015-54-3

Product Name Alternative

LY-2606368 dihydrochloride | LY 2606368 dihydrochloride

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 32 mg/mL

Smiles

COC1=C (C (=CC=C1) OCCCN) C2=CC (=NN2) NC3=NC=C (N=C3) C#N.Cl.Cl

Molecular Formula

C18H21Cl2N7O2

Molecular Weight

438.311

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

2-Pyrazinecarbonitrile, 5-[[5-[2- (3-aminopropoxy) -6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-, hydrochloride (1:2)

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