LRRK2-IN-1
A potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay) ; shows modest activity against LRRK2 A2016T (IC50=2.45 uM) and LRRK2 A2016T+G2019S mutant (IC50=3.08 uM) ; also inhibits DCLK1 (IC50=2.61 nM) and 2 (IC50=45 nM) ; induces dephosphorylation of Ser910 and Ser935 of LRRK2 and alters the cytoplasmic localisation of LRRK2.
Product Specifications
CAS Number
1234480-84-2
Product Name Alternative
LRRK 2-IN-1
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1N (C) C2=CN=C (NC3=CC=C (C (N4CCC (N5CCN (C) CC5) CC4) =O) C=C3OC) N=C2N (C) C6=CC=CC=C16
Molecular Formula
C31H38N8O3
Molecular Weight
570.6852
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4- (4-methyl-1-piperazinyl) -1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-
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