Epetraborole hydrochloride
Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.Bacterial Infection Phase 2 Discontinued
Product Specifications
CAS Number
1234563-16-6
Product Name Alternative
GSK2251052 hydrochloride | AN3365
Purity
>98% (HPLC)
Solubility
H2O: ≥ 28 mg/mL
Smiles
B1 (C2=C (C=CC=C2OCCCO) C (O1) CN) O.Cl
Molecular Formula
C11H17BClNO4
Molecular Weight
273.521
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Propanol, 3-[[ (3S) -3- (aminomethyl) -1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1)
Available Sizes
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