TRX-0237 Methylate
TRX-0237 Methylate (LMTX) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity; disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways; demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.Alzheimer Disease Phase 3 Clinical (In Vitro) :Leucomethylene blue (100 nM, 48 h) mesylate not only decreases the tau and p-tau expression levels, but also reversed the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels.
Product Specifications
CAS Number
1236208-20-0
Product Name Alternative
LMTX | Hydromethylthionine | Methylene blue
Purity
>98% (HPLC)
Solubility
H2O : ≥ 31 mg/mL 64.91 mM
Smiles
CN (C) C1=CC2=C (C=C1) NC3=C (S2) C=C (C=C3) N (C) C.CS (=O) (=O) O.CS (=O) (=O) O
Molecular Formula
C17H21N3O3S2
Molecular Weight
379.493
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,7-bis (dimethylamino) phenothiazin-5-ium methanesulfonate
Available Sizes
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