GIBH-130
A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM) ; modulates the release of detrimental proinflammatory cytokines; exhibits in vivo efficacy of cognitive impairment in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models.Alzheimer's Disease Phase 1 Clinical.
Product Specifications
CAS Number
1252608-59-5
Product Name Alternative
GIBH 130 | GIBH130
Purity
>98% (HPLC)
Solubility
< 1 mg/ml refers to the product slightly soluble or insoluble
Smiles
O=C (C1=NN=C (C2=CC=CC=C2) C=C1C) N3CCN (C4=NC=CC=N4) CC3
Molecular Formula
C20H20N6O
Molecular Weight
360.421
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4-methyl-6-phenylpyridazin-3-yl) (4- (pyrimidin-2-yl) piperazin-1-yl) methanone
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