CP21R7
A high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling; promotes rapid and efficient differentiation of human pluripotent stem cells (hPSCs) into vascular endothelial and smooth muscle cells. (In Vitro) :CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.
Product Specifications
CAS Number
125314-13-8
Product Name Alternative
CP21
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (C (C1=CC=CC (N) =C1) =C2C3=CN (C) C4=C3C=CC=C4) NC2=O
Molecular Formula
C19H15N3O2
Molecular Weight
317.3413
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrole-2,5-dione, 3- (3-aminophenyl) -4- (1-methyl-1H-indol-3-yl) -
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