PF-4708671
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Product Specifications
CAS Number
1255517-76-0
Product Name Alternative
PF4708671 | PF-4708671 | PF 4708671
Purity
>98% (HPLC)
Solubility
Ethanol: 8 mg/mL (20.49 mM) ; DMSO: 30 mg/mL (76.84 mM)
Smiles
FC (C1=CC=C2NC (CN3CCN (C4=NC=NC=C4CC) CC3) =NC2=C1) (F) F
Molecular Formula
C19H21F3N6
Molecular Weight
390.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((4- (5-ethylpyrimidin-4-yl) piperazin-1-yl) methyl) -5- (trifluoromethyl) -1H-benzo[d]imidazole
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