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PF-4708671

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

Product Specifications

CAS Number

1255517-76-0

Product Name Alternative

PF4708671 | PF-4708671 | PF 4708671

Purity

>98% (HPLC)

Solubility

Ethanol: 8 mg/mL (20.49 mM) ; DMSO: 30 mg/mL (76.84 mM)

Smiles

FC (C1=CC=C2NC (CN3CCN (C4=NC=NC=C4CC) CC3) =NC2=C1) (F) F

Molecular Formula

C19H21F3N6

Molecular Weight

390.41

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

2- ((4- (5-ethylpyrimidin-4-yl) piperazin-1-yl) methyl) -5- (trifluoromethyl) -1H-benzo[d]imidazole

Available Sizes

Frequently Asked Questions

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