UNC0638
A potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively; very weak activity against JmjD2E and DNMT1; inactive against EZH2, SETD7, DOT1L and SETD8; reduces the clonogenicity of MCF7 cells and the abundance of H3K9me2.
Product Specifications
CAS Number
1255580-76-7
Product Name Alternative
UNC 0638 | UNC-0638
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
COC1=CC2=C (NC3CCN (C (C) C) CC3) N=C (C4CCCCC4) N=C2C=C1OCCCN5CCCC5
Molecular Formula
C30H47N5O2
Molecular Weight
509.7265
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1- (1-methylethyl) -4-piperidinyl]-7-[3- (1-pyrrolidinyl) propoxy]-
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