(-) -Epicatechin gallate
(-) -Epicatechin gallate is a flavan-3-ol, a type of flavonoid, present in green tea. (In Vitro) : (-) -Epicatechin gallate (Epicatechin gallate) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. (In Vivo) : (-) -Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber) . Following intravenous injection of (-) -Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h kg. The Vdss is 12.39 L/kg.
Product Specifications
CAS Number
1257-08-5
Product Name Alternative
ECG
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=C (O[C@H]1[C@@H] (C2=CC=C (O) C (O) =C2) OC3=C (C (O) =CC (O) =C3) C1) C4=CC (O) =C (O) C (O) =C4
Molecular Formula
C22H18O10
Molecular Weight
442.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[ (2R,3R) -2- (3,4-dihydroxyphenyl) -5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
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