KHS-101
KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM) ; works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo.
Product Specifications
CAS Number
1262770-73-9
Product Name Alternative
KHS101
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
DMSO: 15 mg/mL; Ethanol: 15 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CC (C) CNC1=NC (=NC=C1) NCC2=CSC (=N2) C3=CC=CC=C3
Molecular Formula
C18H21N5S
Molecular Weight
339.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N4-isobutyl-N2- ((2-phenylthiazol-4-yl) methyl) pyrimidine-2,4-diamine
Available Sizes
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