KN-62
KN-62 is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900 nM for rat brain CaMK II; potently antagonizes ATP-stimulated Ba2+ influx into fura-2 loaded human lymphocytes with IC50 of 12.7 nM, inhibits ATP-stimulated ethidium+ uptake with IC50 of 13.1 nM; causes hypertension and tachycardia in rats, associated with the diminished rate of GABA release in cerebrospinal fluid.
Product Specifications
CAS Number
127191-97-3
Product Name Alternative
KN 62 | KN62
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CN (C (CC1=CC=C (C=C1) OS (=O) (=O) C2=CC=CC3=C2C=CN=C3) C (=O) N4CCN (CC4) C5=CC=CC=C5) S (=O) (=O) C6=CC=CC7=C6C=CN=C7
Molecular Formula
C38H35N5O6S2
Molecular Weight
721.9
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Isoquinolinesulfonic acid, 4-[ (2S) -2-[ (5-isoquinolinylsulfonyl) methylamino]-3-oxo-3- (4-phenyl-1-piperazinyl) propyl]phenyl ester
Available Sizes
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