BV6
A small molecule, bivalent IAP antagonist that binds to the c-IAP1 and XIAP BIR2-BIR3 domains with Kd of 0.46 and 0.029 nM, respectively; results in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs; also induces induce TNFα-dependent cell death, exhibits single-agent cell killing activity in EVSA-T cell line (IC50=14 nM) .
Product Specifications
CAS Number
1001600-56-1
Product Name Alternative
BV 6 | BV-6
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 58 mg/mL
Smiles
O=C ([C@H]1N (C ([C@H] (C2CCCCC2) NC ([C@@H] (NC) C) =O) =O) CCC1) N[C@@H] (C (C3=CC=CC=C3) C4=CC=CC=C4) C (NCCCCCCNC ([C@@H] (NC ([C@H]5N (C ([C@H] (C6CCCCC6) NC ([C@@H] (NC) C) =O) =O) CCC5) =O) C (C7=CC=CC=C7) C8=CC=CC=C8) =O) =O
Molecular Formula
C70H96N10O8
Molecular Weight
1205.573
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Phenylalaninamide, 4,4'- (1,6-hexanediyl) bis[N-methyl-L-alanyl- (2S) -2-cyclohexylglycyl-L-prolyl-β-phenyl-
Available Sizes
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