MX69
A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM; induces ubiquitination of endogenous MDM2, results in activation of p53 and inhibition of XIAP, and induces cell apoptosis and death in cancer cells; shows significant apoptotic and anti-proliferative effects on MDM2-expressing cancer cells both in vitro and in vivo, with minimal inhibitory effect on normal human hematopoiesis.
Product Specifications
CAS Number
1005264-47-0
Product Name Alternative
MX 69 | MX-69
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=S (C1=CC2=C (NC (C3=CC=C (C (O) =O) C=C3) C4C2C=CC4) C=C1) (NC5=C (C) C (C) =CC=C5) =O
Molecular Formula
C27H26N2O4S
Molecular Weight
474.57134
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-{8-[ (3,4-Dimethylphenyl) sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl}benzoic acid
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