Daclatasvir

A potent HCV NS5A inhibitor with EC50 of <50 pM against genotype 1 replicons; exhibits picomolar EC (50) towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture.HCV Infection Approved (In Vitro) :Daclatasvir (BMS-790052) demonstrates potent inhibitory activity towards all genotypes tested, with EC50 values ranging from 9 pM to 146 pM. Daclatasvir inhibits HCV replicon genotype 1a, 1b, 2a, 3a, 4a and 5a with EC50 values of 50 pM, 9 pM, 71 pM, 146 pM, 12 pM and 33 pM, respectively. Daclatasvir is a potent inhibitor of the JFH-1 genotype 2a infectious virus that replicates in cell culture (EC50=28 pM) . Daclatasvir (BMS-790052) binds tightly to NS5A33-202 and NS5A26-202 with Kds of 8 nM and 210 nM, respectively. (In Vivo) :Daclatasvir (BMS-790052; 30 mg/kg; oral administration; daily; for 27 days) treatment reduces serum HCV RNA titers very rapidly by ~1.5 log10 at day 3.

Product Specifications

CAS Number

1009119-64-5

Product Name Alternative

BMS-790052 | EBP 883 | BMS 790052

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 40 mg/mL

Smiles

COC (=O) N[C@@H] (C (C) C) C (=O) N1CCC[C@H]1C1=NC=C (N1) C1=CC=C (C=C1) C1=CC=C (C=C1) C1=CN=C (N1) [C@@H]1CCCN1C (=O) [C@@H] (NC (=O) OC) C (C) C |r, c:19,25,27,32,34,39, t:17,23,30,37|

Molecular Formula

C40H50N8O6

Molecular Weight

738.875

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Carbamic acid, N, N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl- (2S) -2,1-pyrrolidinediyl[ (1S) -1- (1-methylethyl) -2-oxo-2,1-ethanediyl]]]bis-, C, C'-dimethyl ester