Gefapixant
Gefapixant (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer) ; displays no inhibitory impact on any non-P2X3 subunit containing receptors (IC50 >10,000 nM at recombinant homotrimeric hP2X1, hP2X2, hP2X4, rP2X5 and hP2X7 channels) ; markedly and significantly reduced objective cough frequency in clinical trials.Asthma Phase 2 Clinical.
Product Specifications
CAS Number
1015787-98-0
Product Name Alternative
AF-219 | MK-7264
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM ((< 1 mg/ml)
Smiles
O=S (C1=CC (OC2=CN=C (N) N=C2N) =C (C (C) C) C=C1OC) (N) =O
Molecular Formula
C14H19N5O4S
Molecular Weight
353.397
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-[ (2,4-diaminopyrimidin-5-yl) oxy]-2-methoxy-4- (propan-2-yl) benzene-1-sulfonamide
Available Sizes
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