SGI-1027
SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B; induces selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B in different cancer cell lines.
Product Specifications
CAS Number
1020149-73-8
Product Name Alternative
SGI1027 | SGI 1027
Purity
>98% (HPLC)
Solubility
DMSO: 27 mg/mL
Smiles
O=C (NC1=CC=C (NC2=NC (N) =NC (C) =C2) C=C1) C3=CC=C (NC4=CC=NC5=CC=CC=C45) C=C3
Molecular Formula
C27H23N7O
Molecular Weight
461.5178
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[4-[ (2-amino-6-methyl-4-pyrimidinyl) amino]phenyl]-4- (4-quinolinylamino) -
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