ZM39923 hydrochloride
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2) with IC50 of 10 nM; ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2; alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival; significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.
Product Specifications
CAS Number
1021868-92-7
Product Name Alternative
ZM-39923 hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 47 mg/mL
Smiles
CC (C) N (CCC (=O) C1=CC2=CC=CC=C2C=C1) CC3=CC=CC=C3.Cl
Molecular Formula
C23H26ClNO
Molecular Weight
367.9117
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Propanone, 3-[ (1-methylethyl) (phenylmethyl) amino]-1- (2-naphthalenyl) -, hydrochloride (1:1)
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