CEP-28122
A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg) .
Product Specifications
CAS Number
1022958-60-6
Product Name Alternative
CEP28122 | CEP 28122 | CEP28122
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C ([C@H]1[C@] (C2) ([H]) C=C[C@]2 ([H]) [C@H]1NC3=NC (NC4=CC=C5C (CC[C@@H] (N6CCOCC6) CC5) =C4OC) =NC=C3Cl) N
Molecular Formula
C28H35ClN6O3
Molecular Weight
539.0689
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[ (7S) -6,7,8,9-tetrahydro-1-methoxy-7- (4-morpholinyl) -5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R) -
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