(-) -Huperzine A
A naturally occurring sesquiterpene alkaloid that a reversible and selective inhibitor of acetylcholinesterase (AChE) ; has been used for improving memory, cognitive and behavioral function in Alzheimer's disease; activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.Alzheimer's Disease Approved (In Vitro) : (-) -Huperzine A (1 μM; 2 hours) attenuates Aβ23-35 (20 μM) -induced neuronal injury. (-) -Huperzine A (100 μM) reversibly inhibits the NMDA-induced current (IC50=126 μM) in whole-cell voltage-clamp recording in CA1 pyramidal neurons acutely dissociated from rat hippocampus. (In Vivo) : (-) -Huperzine A (0.1-0.2 mg/kg; i.p.; daily; for 12 days) can alleviate the cognitive dysfunction and neuronal degeneration induced by i.c.v. infusion of beta-amyloid protein- (1-40) in rats.
Product Specifications
CAS Number
102518-79-6
Product Name Alternative
Huperzine A
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1) C=CC2=C1C[C@H]3/C ([C@@]2 (N) CC (C) =C3) =C\C
Molecular Formula
C15H18N2O
Molecular Weight
242.3162
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5,9-Methanocycloocta[b]pyridin-2 (1H) -one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E) -
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