GNE-477
A potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR; inhibits MCF7.1 cell proliferation with EC50 of 143 nM; displays desirable pharmacokinetic properties, exhibits stasis in a PC3 tumor growth inhibition study.
Product Specifications
CAS Number
1032754-81-6
Product Name Alternative
GNE477 | GNE 477
Purity
>98% (HPLC)
Solubility
DMSO: < 9.2 mg/mL
Smiles
NC1=NC=C (C2=NC (N3CCOCC3) =C4C (C (C) =C (CN5CCN (S (=O) (C) =O) CC5) S4) =N2) C=N1
Molecular Formula
C21H28N8O3S2
Molecular Weight
504.6288
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Pyrimidinamine, 5-[7-methyl-6-[[4- (methylsulfonyl) -1-piperazinyl]methyl]-4- (4-morpholinyl) thieno[3,2-d]pyrimidin-2-yl]-
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