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D-alpha-Hydroxyglutaric acid disodium salt

A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.

Product Specifications

CAS Number

103404-90-6

Product Name Alternative

D-2-HG | D-2-hydroxyglutarate

Purity

>98% (HPLC)

Solubility

H2O: ≥ 32 mg/mL

Smiles

[O-]C (CC[C@H] (C ([O-]) =O) O) =O.[Na+].[Na+]

Molecular Formula

C5H6Na2O5

Molecular Weight

192.08

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Pentanedioic acid, 2-hydroxy-, disodium salt, (2R) -

Available Sizes

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