D-alpha-Hydroxyglutaric acid disodium salt
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
Product Specifications
CAS Number
103404-90-6
Product Name Alternative
D-2-HG | D-2-hydroxyglutarate
Purity
>98% (HPLC)
Solubility
H2O: ≥ 32 mg/mL
Smiles
[O-]C (CC[C@H] (C ([O-]) =O) O) =O.[Na+].[Na+]
Molecular Formula
C5H6Na2O5
Molecular Weight
192.08
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pentanedioic acid, 2-hydroxy-, disodium salt, (2R) -
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog