MK-4827 hydrochloride
A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10 100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.Ovarian Cancer Approved.
Product Specifications
CAS Number
1038915-64-8
Product Name Alternative
Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1CC (CNC1) C2=CC=C (C=C2) N3C=C4C=CC=C (C4=N3) C (=O) N.Cl
Molecular Formula
C19H21ClN4O
Molecular Weight
356.8492
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indazole-7-carboxamide, 2-[4- (3S) -3-piperidinylphenyl]-, hydrochloride (1:1)
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