MI-2
MI-2 (MALT1 inhibitor) is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84 uM, displays little activity against the related caspase family members caspase-3, -8, and -9; inhibits cleavage of MALT1 substrates, which is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation; specifically suppress ABC-DLBCL in vitro and in vivo, exhibits GI 50 of 0.2, 0.5, 0.4, and 0.4 uM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells respectively, inhibits nuclear translocation of RelB and p50, and decreases Bcl-xL levels in CLL cells.
Product Specifications
CAS Number
1047953-91-2
Product Name Alternative
MI 2 | MI2
Field of Research
Epigenetics & Chromatin
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
O=C (NC1=CC=C (N2N=C (OCCOC) N=C2C3=CC=C (Cl) C (Cl) =C3) C=C1) CCl
Molecular Formula
C19H17Cl3N4O3
Molecular Weight
455.7223
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetamide, 2-chloro-N-[4-[5- (3,4-dichlorophenyl) -3- (2-methoxyethoxy) -1H-1,2,4-triazol-1-yl]phenyl]-
Available Sizes
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