PND-1186
PND-1186 (VS-4718) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. Phase 1. (In Vitro) :PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397.In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 μM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h. (In Vivo) :PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis.
Product Specifications
CAS Number
1061353-68-1
Product Name Alternative
SR 2516 | VS-4718
Purity
>98% (HPLC)
Solubility
DMSO: 24 mg/mL (47.85 mM)
Smiles
O=C (NC) C1=CC=CC=C1NC2=CC (NC3=C (OC) C=C (N4CCOCC4) C=C3) =NC=C2C (F) (F) F
Molecular Formula
C25H26F3N5O3
Molecular Weight
501.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((2- ((2-methoxy-4-morpholinophenyl) amino) -5- (trifluoromethyl) pyridin-4-yl) amino) -N-methylbenzamide.
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