Eplerenone
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors. (In Vitro) :Eplerenone inhibits the human mineralocorticoid receptor with IC50 value of 0.081 μM. (In Vivo) :Eplerenone (oral, 200 mg/kg/day for 3 months) significantly reduces oxidative stress and atherosclerosis progression in atherosclerotic apolipoprotein edeficient (EO) mice.
Product Specifications
CAS Number
107724-20-9
Product Name Alternative
CGP 30083 | (+) -Eplerenone | Epoxymexrenone | SC-6110 | SC-66110
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: <1 mg/mL (<1 mM) ; Water: <1 mg/mL (<1 mM) ; DMSO: <1 mg/mL (<1 mM)
Smiles
C[C@]12CCC (C=C1C[C@@H] (C (OC) =O) [C@@H]3[C@]24[C@@H] (C[C@@]5 (C) [C@H]3CC[C@@]56CCC (O6) =O) O4) =O
Molecular Formula
C24H30O6
Molecular Weight
414.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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