GDC-0326
A potent, selective, orally available PI3Kα inhibitor with Ki of 0.2 nM; displays 133, 20 and 33-fold selectivity over PI3Kβ, PI3Kδ and PI3Kγ, respectively; inhibits MCF7-neo/HER2 and PC3 cells proliferation with IC50 of 0.1 uM and 2.2 uM, respectively; reduces tumor growth as well as vascular area in vivo, also reduces the incidence of liver and lymph node metastasis.
Product Specifications
CAS Number
1282514-88-8
Product Name Alternative
GDC 0326 | GDC0326
Purity
>98% (HPLC)
Solubility
DMSO: 69 mg/mL (180.5 mM) ; Water: Insoluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
C[C@H] (OC1=CC=C2C3=NC (C4=NC=NN4C (C) C) =CN3CCOC2=C1) C (N) =O
Molecular Formula
C19H22N6O3
Molecular Weight
382.424
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -2- ((2- (1-isopropyl-1H-1,2,4-triazol-5-yl) -5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl) oxy) propanamide
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