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RAD51 Inhibitor B02

A specific human RAD51 recombinase inhibitor with IC50 of 27.4 uM; shows no activity against E. coli homologue RecA (IC50>250 uM), disrupts RAD51 binding to DNA and specifically inhibits the DNA strand exchange activity of human RAD51; inhibits homologous recombination (HR) and increases cell sensitivity to DNA damage, sensitizes multiple myeloma cells to doxorubicin.

Product Specifications

CAS Number

1290541-46-6

Product Name Alternative

B02 | B-02 | B 02

Field of Research

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 37 mg/mL

Smiles

O=C1N (CC2=CC=CC=C2) C (/C=C/C3=CC=CN=C3) =NC4=C1C=CC=C4

Molecular Formula

C22H17N3O

Molecular Weight

339.38988

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4 (3H) -Quinazolinone, 3- (phenylmethyl) -2-[ (1E) -2- (3-pyridinyl) ethenyl]-

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