RAD51 Inhibitor B02
A specific human RAD51 recombinase inhibitor with IC50 of 27.4 uM; shows no activity against E. coli homologue RecA (IC50>250 uM), disrupts RAD51 binding to DNA and specifically inhibits the DNA strand exchange activity of human RAD51; inhibits homologous recombination (HR) and increases cell sensitivity to DNA damage, sensitizes multiple myeloma cells to doxorubicin.
Product Specifications
CAS Number
1290541-46-6
Product Name Alternative
B02 | B-02 | B 02
Field of Research
Epigenetics & Chromatin; Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 37 mg/mL
Smiles
O=C1N (CC2=CC=CC=C2) C (/C=C/C3=CC=CN=C3) =NC4=C1C=CC=C4
Molecular Formula
C22H17N3O
Molecular Weight
339.38988
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4 (3H) -Quinazolinone, 3- (phenylmethyl) -2-[ (1E) -2- (3-pyridinyl) ethenyl]-
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