GSK1324726A
A potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively; exhibits growth inhibition with a median growth IC50 value of 75 nM in neuroblastoma cell lines; oral administration to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression.
Product Specifications
CAS Number
1300031-52-0
Product Name Alternative
I-BET726 | GSK 1324726A | GSK-1324726A | I-BET 726
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
O=C (O) C1=CC=C (C2=CC3=C (N (C (C) =O) [C@@H] (C) C[C@H]3NC4=CC=C (Cl) C=C4) C=C2) C=C1
Molecular Formula
C25H23ClN2O3
Molecular Weight
434.9147
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 4-[ (2S,4R) -1-acetyl-4-[ (4-chlorophenyl) amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-
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