Dorzolamide hydrochloride
Dorzolamide Hcl (L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor. (In Vitro) :Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM) . (In Vivo) :Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively) .
Product Specifications
CAS Number
130693-82-2
Product Name Alternative
L-671,152 | MK-507
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 14 mg/mL (38.79 mM)
Smiles
O=S (C (S1) =CC ([C@@H] (NCC) C[C@@H]2C) =C1S2 (=O) =O) (N) =O.[H]Cl
Molecular Formula
C10H17ClN2O4S3
Molecular Weight
360.9
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4S,6S) -4- (ethylamino) -6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
Available Sizes
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