EMA401
EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM; EMA401 is a novel peripherally-restricted analgesic, may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways.Pain Phase 2 Clinical (In Vivo) :EMA401 (10 mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI) .
Product Specifications
CAS Number
1316755-16-4
Product Name Alternative
EMA 401 | EMA-401 | Olodanrigan
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 34 mg/mL
Smiles
COC1=C (C2=C (CN (C (C2) C (=O) O) C (=O) C (C3=CC=CC=C3) C4=CC=CC=C4) C=C1) OCC5=CC=CC=C5
Molecular Formula
C32H29NO5
Molecular Weight
507.5764
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Isoquinolinecarboxylic acid, 2- (2,2-diphenylacetyl) -1,2,3,4-tetrahydro-6-methoxy-5- (phenylmethoxy) -, (3S) -
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