AZD-4635
AZD-4635 (HTL 1071) is a potent, selective and orally available adenosine 2A receptor (A2AR) inhibitor with Ki of 1.7 nM, > 30-fold selectivity over other adenosine receptors; reverses the inhibitory effects of different concentrations of adenosine in CHO cells stably expressing human A2AR with IC50 of 0.1 nM (incubated with 0.1 uM adenosine) ; reverses suppression and restores IFNγ secretion in cells incubated with NECA in ex vivo CD8+ T cell assay; reduces tumor burden and enhances antitumor immunity in vivo.Lung Cancer Phase 2 Clinical (In Vitro) :In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively.
Product Specifications
CAS Number
1321514-06-0
Product Name Alternative
HTL 1071
Purity
>98% (HPLC)
Solubility
DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
NC1=NC (C2=CC=C (F) C=C2) =C (C3=CC (C) =NC (Cl) =C3) N=N1
Molecular Formula
C15H11ClFN5
Molecular Weight
315.736
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- (2-chloro-6-methylpyridin-4-yl) -5- (4-fluorophenyl) -1,2,4-triazin-3-amine
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