Pheniramine maleate
Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. (In Vitro) :Pheniramine maleate inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects.Pheniramine maleate regulates cellular Ca2+ transmembrane action, and inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM.Pheniramine maleate (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines.Pheniramine maleate (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively. (In Vivo) :Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats.
Product Specifications
CAS Number
132-20-7
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 71 mg/mL (199.2 mM) ; Water: 71 mg/mL (199.2 mM) ; DMSO: 71 mg/mL (199.2 mM)
Smiles
CN (C) CCC (C1=CC=CC=C1) C2=CC=CC=N2.C (=C\C (=O) O) \C (=O) O
Molecular Formula
C16H20N2·C4H4O4
Molecular Weight
356.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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