Penicillin V potassium salt

Penicillin V potassium is a broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. (In Vitro) :Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L.Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile, with a MIC90 of 8 mg/L.Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with a MIC of 0.016 mg/L. (In Vivo) :Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle.Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats.Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L h) .