Itacitinib
A potent and selective JAK1 inhibitor; shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively; orally bioactive.Blood Cancer Phase 2 Clinical (In Vitro) :Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.
Product Specifications
CAS Number
1334298-90-6
Product Name Alternative
INCB-039110
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
N#CCC1 (N2N=CC (C3=C4C (NC=C4) =NC=N3) =C2) CN (C5CCN (C (C6=C (F) C (C (F) (F) F) =NC=C6) =O) CC5) C1
Molecular Formula
C26H23F4N9O
Molecular Weight
553.5142
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Azetidineacetonitrile, 1-[1-[[3-fluoro-2- (trifluoromethyl) -4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4- (7H-pyrrolo[2,3-d]pyrimidin-4-yl) -1H-pyrazol-1-yl]-
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