GSK2606414
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. (In Vitro) :GSK2606414 inhibits PERK activation in cells. (In Vivo) :GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
Product Specifications
CAS Number
1337531-36-8
Product Name Alternative
GSK2606414 | GSK-2606414 | GSK PERK Inhibitor
Purity
>98% (HPLC)
Solubility
Ethanol: 19 mg/mL (42.08 mM) ; DMSO: 90 mg/mL (199.36 mM)
Smiles
FC (C1=CC (CC (N2CCC3=C2C=CC (C4=CN (C) C5=NC=NC (N) =C54) =C3) =O) =CC=C1) (F) F
Molecular Formula
C24H20F3N5O
Molecular Weight
451.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (5- (4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl) indolin-1-yl) -2- (3- (trifluoromethyl) phenyl) ethanone
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