OTS-964
OTS-964 is a dimethylated derivative of OTS514 and potent, selective TOPK inhibitor with IC50 of 28 nM, exhibits excellent in vivo efficacy with liposomal formulation; inhibits the growth of TOPK-positive cells with low IC50 values (A549 IC50=31 nM), decreases autophosphorylation of TOPK (Thr9), as well as phosphorylation of histone H3 (Ser10), in both T47D and LU-99 cells; the liposomal OTS964 causes complete regression of tumors without any detectable toxicity in the xenograft models.
Product Specifications
CAS Number
1338545-07-5
Product Name Alternative
OTS964
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=CC (=C (C2=C1NC (=O) C3=C2C=CS3) C4=CC=C (C=C4) C (C) CN (C) C) O.Cl
Molecular Formula
C23H25ClN2O2S
Molecular Weight
428.9748
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Thieno[2,3-c]quinolin-4 (5H) -one, 9-[4-[ (1R) -2- (dimethylamino) -1-methylethyl]phenyl]-8-hydroxy-6-methyl-, hydrochloride (1:1)
Available Sizes
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