JNJ-42165279
JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.Anxiety Phase 2 Clinical.
Product Specifications
CAS Number
1346528-50-4
Product Name Alternative
JNJ42165279 | JNJ 42165279
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1CN (CCN1CC2=CC3=C (C=C2) OC (O3) (F) F) C (=O) NC4=C (C=CN=C4) Cl
Molecular Formula
C18H17ClF2N4O3
Molecular Weight
410.8024
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperazinecarboxamide, N- (4-chloro-3-pyridinyl) -4-[ (2,2-difluoro-1,3-benzodioxol-5-yl) methyl]-
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