GSK-872
GSK-872 (GSK'872) is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor; interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling; attenuates rat nucleus pulposus (NP) cells death. (In Vitro) :GSK-872 (GSK'872; 0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in human HT-29 cells in a concentration-dependent manner. (In Vivo) :GSK-872 (25 mM; intracerebroventricular injection) can attenuate brain edema and improve neurological function following subarachnoid hemorrhage (SAH) and reduce the number of necrotic cells. GSK-872 can also decrease the protein levels of RIPK3 and MLKL, and cytoplasmic translocation and expression of HMGB1, an important pro-inflammatory protein.
Product Specifications
CAS Number
1346546-69-7
Product Name Alternative
GSK 872
Purity
>98% (HPLC)
Solubility
DMSO: 71 mg/mL (185.1 mM) ; Ethanol: 38 mg/mL (99.1 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=S (C1=CC=C2N=CC=C (NC3=CC=C (SC=N4) C4=C3) C2=C1) (C (C) C) =O
Molecular Formula
C19H17N2O2S2
Molecular Weight
383.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-5-benzothiazolyl-6-[ (1-methylethyl) sulfonyl]-4-quinolinamine
Available Sizes
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