Lamivudine
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM. (In Vitro) :Lamivudine (1 μM) is potent inhibitor of hepatitis B virus (HBV) replication, shows antiviral activity in primary duck hepatocyte (PDH) cultures derived from ducklings congenitally infected with the duck hepatitis B virus (DHBV) .Lamivudine (0-20 μM; 2, 4, 9 d) inhibits DHBV replication with 50% inhibitory concentration of 0.55 μM.Lamivudine, combinded with penciclovir (9-[2-hydroxy-1- (hydroxymethyl) ethoxymethyl]guanine [PCV]), (1 μM; 2, 4, 9 d) shows synergistic effect, acts potent function in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV. (In Vivo) :Lamivudine (20-500 mg/kg/d; p.o.; 15 or 45 d) causes oxidative stress and is toxic to rat liver.Lamivudine (50 mg/kg; i.p.; single dose) penetrates well in CNS and localizes in brain regions susceptible to HIV neurodegeneration in rat.
Product Specifications
CAS Number
134678-17-4
Product Name Alternative
(-) -BCH 189 | Epivir | Epivir-HBV | 3TC
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 46 mg/mL (200.64 mM) ; DMSO: 46 mg/mL (200.64 mM)
Smiles
O=C1N=C (N) C=CN1[C@@H]2CS[C@H] (CO) O2
Molecular Formula
C8H11N3O3S
Molecular Weight
229.26
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-amino-1-[ (2R,5S) -2- (hydroxymethyl) -1,3-oxathiolan-5-yl]pyrimidin-2-one
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