GNE-7915
A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.Parkinson's Disease Preclinical.
Product Specifications
CAS Number
1351761-44-8
Product Name Alternative
GNE7915 | GNE 7915
Purity
>98% (HPLC)
Solubility
DMSO: 14.33 mg/mL
Smiles
O=C (C1=CC (OC) =C (NC2=NC=C (C (F) (F) F) C (NCC) =N2) C=C1F) N3CCOCC3
Molecular Formula
C19H21F4N5O3
Molecular Weight
443.3954
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Methanone, [4-[[4- (ethylamino) -5- (trifluoromethyl) -2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
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