WEHI-345
A potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM; displays negligible activity (>10 uM) against RIPK1, RIPK4 and RIPK5; delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement; prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.
Product Specifications
CAS Number
1354825-58-3
Product Name Alternative
WEHI-345 | WEHI345 | WEHI 345
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (NCC (C) (N1N=C (C2=CC=C (C) C=C2) C3=C (N) N=CN=C31) C) C4=CC=NC=C4
Molecular Formula
C22H23N7O
Molecular Weight
401.4643
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Pyridinecarboxamide, N-[2-[4-amino-3- (4-methylphenyl) -1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-
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