AZD3463
AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. (In Vitro) :AZD-3463 (0-50 μM; 72 h) suppresses the viability and proliferation of both wild type and mutant ALK NB cells.AZD-3463 (10 μM; 0-4 h) effectively inhibits ALK-mediated PI3K/AKT/mTOR signaling and induces apoptosis and autophagy in NB cells.AZD-3463 (0-100 nM; 4 h) inhibits FLT3-ITD-mediated activation of AKT, ERK1/2 and p38 in a dose-dependent manner in MOLM-13 and MV4-11 cells. (In Vivo) :AZD3463 (15 mg/kg; i.p.; once daily for 2 days) inhibits tumor growth in different orthotopic NB xenograft mouse models.
Product Specifications
CAS Number
1356962-20-3
Product Name Alternative
AZD3463 | AZD 3463 | AZD-3463
Purity
>98% (HPLC)
Solubility
DMSO: 24 mg/mL (53.45 mM)
Smiles
ClC1=CN=C (NC2=CC=C (N3CCC (N) CC3) C=C2OC) N=C1C4=CNC5=C4C=CC=C5
Molecular Formula
C24H25ClN6O
Molecular Weight
448.95
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- (4-aminopiperidin-1-yl) -2-methoxyphenyl) -5-chloro-4- (1H-indol-3-yl) pyrimidin-2-amine.
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