Belizatinib
A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM; exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.Blood Cancer Phase 2 Clinical (In Vitro) :TSR-011 has antitumour activity in the clinical trials. (In Vivo) :TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.
Product Specifications
CAS Number
1357920-84-3
Product Name Alternative
TSR-011 | TSR011
Purity
>98% (HPLC)
Solubility
DMSO: ≥300 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NC1=NC2=CC=C (CN3CCC (C (C) (O) C) CC3) C=C2N1[C@H]4CC[C@@H] (C (NC (C) C) =O) CC4) C5=CC=C (F) C=C5
Molecular Formula
C33H44FN5O3
Molecular Weight
577.745
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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